Design and Preparation of Zaltoprofen-Nicotinamide Pharmaceutical Cocrystals via Liquid Assisted Grinding Method

Pharmaceutical Cocrystals: An Overview

In the last few years, a large number of drugs have been discovered with low aqueous solubility. Among these recently discovered drugs, about 60-70% of the compounds are related to the BCS Class II (low solubility/high permeability) and IV (low solubility/ low permeability)[1,2]. Many active pharmaceutical ingredients (APIs) have not been developed in formulations due to low aqueous solubility,...

chemical recycling of polycarbonate waste using conventional heating and microwave assisted method

پلی کربنات یکی از پلاستیکهای مهمی است که به صورت گسترده در تولید لوحهای فشرده، قطعات رایانه، مواد ساختمانی و غیره مورد استفاده قرار می گیرد. این پلیمر بصورت عمده از تراکم مونومر بیس فنولa (bpa) و کربنیل کلرید یا دی متیل کربنات ها بدست می آید. در سالهای اخیر بازیافت شیمیایی پلی کربنات بیشتر مورد توجه بوده است. بازیافت شیمیایی پلی کربنات برای بدست آوردن مواد اولیه آن با روشهای متفاوتی مانند تجزی...

Interconversion between different stoichiometric forms of a three-component crystal via liquid-assisted grinding.

A second polymorphic form of a 1 : 2 : 3 pamoate : DABCO : water salt has been obtained by liquid-assisted grinding, and it is shown that interconversion between this salt and a salt with 1 : 1 : 2 stoichiometry is facile via liquid-assisted grinding with additional amounts of pamoic acid (to generate the 1 : 1 : 2 salt) or DABCO (to generate the 1 : 2 : 3 salt).

Pharmaceutical Cocrystals and Their Physicochemical Properties

This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystals and, hopefully, draw closer the fields of crystal engineering and pharmaceutical sciences.

Towards more Efficient Screening of Pharmaceutical Cocrystals